Andrea Pettit, a junior undergraduate student in the Immunology and Medical Microbiology program, was the winner in the Undergraduate Research Poster category at the 53rd Van Liere Research Conference held March 22-23 at the WVU Health Sciences Center.
Andrea works in the laboratory of Jennifer Franko, Ph.D. The title of her poster was “The influence of sex chromosome-specific gut microbiomes on a sexually dimorphic immune response.” Her project utilized 16s rRNA sequencing and metagenomics analysis to evaluate differences in gut microbial communities between male and female four-core genotype (FCG) mice. Interestingly, her data identified both hormonal and sex-chromosome complement influences on gut microbiome diversity. Since the gut microbiome plays an important role in regulating immune homeostasis, such differences in microbiome diversity may contribute to the variances seen in male vs. female immune responses. Andrea investigated the influence of XX vs. XY sex-chromosome complement-specific microbiomes on immune responses to heat-killed Streptococcus pneumoniae immunization and propanil exposure.
Dr. Van Liere served as the Dean of the School of Medicine from 1937 until 1960. He developed the two-year medical school into a four-year accredited program. He was also a consultant to the Surgeon General of the United States. Van Liere Memorial Convocation and WVU Health Sciences Research Day is named in his honor.
Manish Ranjan, M.D., WVU Rockefeller Neuroscience Institute clinical research instructor in the Department of Neurosurgery, is a joint first author of the study currently featured in Brain – A Journal of Neurology.
Obstetricians and midwives often warn new mothers about postpartum depression. They might mention what symptoms women should look out for—such as crying spells or extreme irritability—and where they can turn for help. But people who have strokes may not learn that they, too, are at risk for depression.
A West Virginia University Department of Orthopaedics research study is seeking participants with aches and pains from Berkeley, Doddridge, Greenbrier, Jackson, Marion, Monongalia, Wood, and surrounding counties in West Virginia; Fayette County in Pennsylvania; and Washington County in Ohio for a self-help workshop.